| Reference values for B cell subpopulations from infancy to adulthood. | |
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MedLine Citation:
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PMID: 20854328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The composition of the peripheral blood lymphocyte compartment underlies developmental changes during ontogeny. Recently, several new B cell populations have been characterized which were suggested to develop in an age-dependent manner. However, age-dependent reference values for distinct B cell populations have rarely been reported. Therefore, we have characterized developmental changes in peripheral B cell populations from infancy to adulthood in order to define age-dependent reference values. Using a flow cytometric approach we analysed the frequencies as well as the absolute counts of naive, switched and non-switched memory B cells, CD27-negative memory B cells, transitional B cells as well as CD21(low) CD38(low) B cells from neonates up to the age of 50 years. Most of the B cell subsets showed age-dependent developmental changes: while the peripheral B cell pool during infancy is characterized predominantly by transitional and naive B cells, the fraction of switched and non-switched memory B cells increases gradually with age. CD21(low) CD38(low) B cells as well as plasmablasts do not exhibit developmental changes. In summary, we could demonstrate particular changes in the peripheral blood B cell compartment during ontogeny. This study provides reference values of different B cell subpopulations offering comparability for studies addressing disturbed peripheral B cell development in immunodeficiency, autoimmunity or B cell reconstitution following cell-depleting therapies. |
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Authors:
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H Morbach; E M Eichhorn; J G Liese; H J Girschick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-20 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 162 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-01-10 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 271-9 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors; Clinical and Experimental Immunology © 2010 British Society for Immunology. |
Affiliation:
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Department of Pediatrics, University of Würzburg, Germany. morbach_h@klinik.uni-wuerzburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aging / immunology* Antigens, CD19 / metabolism Antigens, CD24 / metabolism Antigens, CD27 / metabolism Antigens, CD38 / metabolism Antigens, CD45 / metabolism B-Lymphocyte Subsets / cytology*, immunology, metabolism Child Child, Preschool Humans Immunoglobulin D / metabolism Immunophenotyping Infant Lymphocyte Count* Membrane Glycoproteins / metabolism Middle Aged Receptors, Complement 3d / metabolism Reference Values Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD19; 0/Antigens, CD24; 0/Antigens, CD27; 0/CD24 protein, human; 0/Immunoglobulin D; 0/Membrane Glycoproteins; 0/Receptors, Complement 3d; EC 3.1.3.48/Antigens, CD45; EC 3.1.3.48/PTPRC protein, human; EC 3.2.2.5/Antigens, CD38; EC 3.2.2.5/CD38 protein, human |
| Comments/Corrections | |
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