Document Detail

Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system.
MedLine Citation:
PMID:  19171584     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: "Reference ranges" are developed when it is impossible or inappropriate to establish "normal ranges" by drawing blood on healthy normal volunteers. Reference ranges for the hematocrit and the blood hemoglobin concentration of newborn infants have previously been reported from relatively small sample sizes by using measurement methods that now are considered outmoded. METHODS: We sought to develop reference ranges for hematocrit and hemoglobin during the neonatal period (28 days) by using very large sample sizes and modern hematology analyzers, accounting for gestational and postnatal age and gender. Data were assembled from a multihospital health care system after exclusion of patients with a high likelihood of an abnormal value and those who were receiving blood transfusions. RESULTS: During the interval from 22 to 40 weeks' gestation, the hematocrit and blood hemoglobin concentration increased approximately linearly. For every week advance in gestational age, the hematocrit increased by 0.64% and the hemoglobin concentration increased by 0.21 g/dL. No difference was seen on the basis of gender. During the 4-hour interval after birth, hematocrit/hemoglobin values of late preterm and term neonates (35-42 weeks' gestation) increased by 3.6% +/- 0.5% (mean +/- SD), those of neonates of 29 to 34 weeks' gestation remained unchanged, and those of <29 weeks' gestation decreased by 6.0% +/- 0.3%. During the first 28 days after birth, an approximately linear decrease in hematocrit/hemoglobin occurred. CONCLUSIONS: The figures presented herein describe reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period, accounting for gestational and postnatal age.
Jeffery Jopling; Erick Henry; Susan E Wiedmeier; Robert D Christensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  123     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e333-7     Citation Subset:  AIM; IM    
Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, Utah, USA.
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MeSH Terms
Hemoglobins / analysis*
Infant, Newborn
Multi-Institutional Systems
Reference Values
Reg. No./Substance:

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