Document Detail


Reference ranges for erythrocyte pyridoxal 5'-phosphate concentration and the erythrocyte aspartate transaminase stimulation test in lactating mothers and their infants.
MedLine Citation:
PMID:  8198054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined reference ranges for erythrocyte pyridoxal 5'-phosphate concentrations (EPLP) and erythrocyte aspartate transaminase basal activities (EASTo) and activation coefficients (alpha EAST) in lactating mothers and infants from data of mothers receiving a vitamin B-6 supplement and infants breast-fed by mothers with adequate vitamin B6 status. The mothers' vitamin B6 status was assessed on the third day postpartum (pp) (n = 91) and at 2 mo (n = 114), 4 mo (n = 117), 6 mo (n = 110), and 9 mo (n = 40) pp and that of the exclusively breast-fed infants at 2 mo (n = 90), 4 mo (n = 106), and 6 mo (n = 99). We also examined 9-mo-old infants (n = 39) who, besides breast milk, had received solids after 6 mo, and 12-mo-old infants (n = 100) who had received solids beginning at 4-6 mo and dairy products at 9 mo. Values indicating deficiency for at least two of the three indexes distinguished the 5-10% of mothers and infants with the lowest vitamin B6 status. The reference ranges for EPLP, EASTo, and alpha EAST for infants and for mothers during the first months of lactation differ from those reported earlier for adults.
Authors:
K Heiskanen; M A Siimes; J Perheentupa; L Salmenperä
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  59     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-24     Completed Date:  1994-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1297-303     Citation Subset:  AIM; IM    
Affiliation:
Children's Hospital, University of Helskini, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aspartate Aminotransferases / blood*
Erythrocytes / metabolism*
Female
Humans
Infant
Infant, Newborn
Lactation / metabolism*
Pyridoxal Phosphate / blood*
Pyridoxine / metabolism
Reference Values
Chemical
Reg. No./Substance:
54-47-7/Pyridoxal Phosphate; 65-23-6/Pyridoxine; EC 2.6.1.1/Aspartate Aminotransferases

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