Document Detail

Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking.
MedLine Citation:
PMID:  18057382     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to re-evaluate the adult C(T) reference values determined by five different immunoassays and by introducing criteria for selecting control subjects.
DESIGN: A prospective multicenter study.
PATIENTS: Three hundred and seventy-five clinically euthyroid subjects.
METHODS: We used five different C(T) immunoassays. Sera were assayed for the concentration of TSH, gastrin, procalcitonin, urea, calcium, and anti-thyroperoxidase antibodies.
RESULTS: Screening for the various potential causes of hypercalcitoninemia led to the exclusion of 23% of the sera. Our reference value analysis dealt with 287 subjects (142 men and 145 women). The proportion of samples in which no C(T) was detected varied from 56% (for assay D) to 88% (for assay C). We observed significant correlations (whose magnitude depended on the assay used) between C(T) levels and age or body mass index (BMI) (primarily in men). The distribution of C(T) levels showed that 4.7, 9.8, 2.5, 6.5, and 8.0% of the values were over 10 pg/ml respectively. These values corresponded essentially to samples from 11 male subjects (median age: 55 years), most of whom were smokers. The highest C(T) values were around twice as high in men than women, and were higher in smokers than non-smokers. Conclusion In clinical practice (and after having excluded the usual causes of raised C(T) levels), the interpretation of C(T) assay results must take into account i) the method used; ii) the patient's gender, age, and weight; and iii) the potential influence of cigarette smoking.
Michèle d'Herbomez; Philippe Caron; Catherine Bauters; Christine Do Cao; Jean-Louis Schlienger; Rémy Sapin; Line Baldet; Bruno Carnaille; Jean-Louis Wémeau;
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  157     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2007-12-20     Revised Date:  2011-07-21    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
Department of Nuclear Medicine, Hôpital Salengro, CHRU, 59037 Lille Cedex, France.
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MeSH Terms
Age Factors
Aged, 80 and over
Antibodies / blood
Calcitonin / blood*
Calcium / blood
Carcinoma, Medullary / diagnosis
Gastrins / blood
Immunoassay / methods
Iodide Peroxidase / immunology
Middle Aged
Prospective Studies
Protein Precursors / blood
Reagent Kits, Diagnostic
Reference Values
Smoking / blood*
Thyroid Neoplasms / diagnosis
Thyrotropin / blood
Tumor Markers, Biological / blood
Urea / blood
Reg. No./Substance:
0/Antibodies; 0/Gastrins; 0/Protein Precursors; 0/Reagent Kits, Diagnostic; 0/Tumor Markers, Biological; 56645-65-9/procalcitonin; 57-13-6/Urea; 7440-70-2/Calcium; 9002-71-5/Thyrotropin; 9007-12-9/Calcitonin; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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