Document Detail

Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy.
MedLine Citation:
PMID:  19228824     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies' positivity. METHODS: We tested 5520 women from the central part of the Czech Republic during the first trimester of pregnancy for serum TSH, anti-TPO and FT4 by chemiluminometric immunoanalysis on an ADVIA Centaur system (Siemens). The reference interval for TSH during the first trimester of pregnancy was determined using the log transformation, and then summarized as the geometrical mean (95% CI); following which, a suitable decision point for anti-TPO positivity was set. RESULTS: The reference interval for TSH was determined to be 0.06-3.67 mU/l. The suppression of TSH was found in 2.93% of the women; a raised concentration of TSH had been found in 4.48% of the women. For anti-TPO, the cut-off was established at 143 kU/l; 11.2% of the pregnant women were found to be anti-TPO positive. CONCLUSION: Determination of the reference interval for TSH during early pregnancy is one of the basic requirements when implementing a general examination of the thyroid gland at the beginning of pregnancy. The decision level for positivity of anti-TPO is more than double the manufacturer's reference interval.
Drahomira Springer; Tomas Zima; Zdena Limanova
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-19
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  160     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  791-7     Citation Subset:  IM    
Department of Clinical Biochemistry and Laboratory Medicine, General Teaching Hospital, First Faculty of Medicine Charles University, U Nemocnice 2, 120 00 Prague, Czech Republic.
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MeSH Terms
Autoantibodies / blood
Case-Control Studies
Chorionic Gonadotropin / blood,  physiology
Iodide Peroxidase / immunology
Predictive Value of Tests
Pregnancy Complications / blood,  diagnosis
Pregnancy Trimester, First / blood*,  physiology*
Reference Values
Reproducibility of Results
Thyroid Diseases / blood,  diagnosis
Thyroid Function Tests / standards*
Thyroid Hormones / blood
Thyrotropin / blood*
Reg. No./Substance:
0/Autoantibodies; 0/Chorionic Gonadotropin; 0/Thyroid Hormones; 9002-71-5/Thyrotropin; EC Peroxidase

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