Document Detail


Reference intervals for blood Cd and Pb in the general population of Sardinia (Italy).
MedLine Citation:
PMID:  20965782     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The reference values (RVs) for blood Cd and Pb of 215 adult subjects non-occupationally exposed and living in Sardinia (insular Italy) were assessed. Age, sex, smoking, alcohol drinking and living area were used to stratify the reference group. After collection from volunteers, samples were acid digested in a microwave oven and metals were determined by sector field inductively coupled plasma mass spectrometry. The RVs expressed as 5th-95th percentiles (geometric mean, GM) were 0.24-1.82μg/l (0.53μg/l) for blood Cd and 13.2-87.3μg/l (33.4μg/l) for blood Pb. Females had GM levels of Cd (0.58μg/l) higher than males (0.49μg/l); subjects aged <40 years had less Cd (0.44μg/l) than old subjects (>60 years; 0.56μg/l); Cd in smokers (1.23μg/l) was 3-times higher than in non-smokers (0.42μg/l) and correlated with the number of cigarettes per day. The alcohol intake and place of living did not influence blood Cd. The GM values of blood Pb in males (44.4μg/l) were higher than in females (24.7μg/l); subjects less than 40 years-old (27.5μg/l) showed lower Pb than elderly individuals (>60 years, 41.2μg/l); drinkers (42.2μg/l) had Pb 2-times higher than non-drinkers (24.4μg/l). Blood Pb was not significantly affected by smoking and place of living. As revealed by multiple linear regression, the predictor variables were, in order of weight, smoke≫age for blood Cd levels, and sex=age≫alcohol for blood Pb levels.
Authors:
Giovanni Forte; Roberto Madeddu; Paola Tolu; Yolande Asara; Juan A Marchal; Beatrice Bocca
Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  214     ISSN:  1618-131X     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  102-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
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