| Reference change values of blood analytes from physically active subjects. | |
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MedLine Citation:
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PMID: 20446091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The analysis of blood constituents allows the detection of various physiological or pathological states when their values are increased or decreased in relation to a well-defined reference group or to themselves if monitored longitudinally. In the latter case, it is important to know the reference change value (RCV) or critical difference, which defines the percentage change that should be exceeded-given the analytical and biological variations inherent to a particular test, in that there is a significant difference between the two consecutive measurements. Our objective was to calculate the biological variation, analytical variation and RCV of the biochemical and hematological parameters in subjects undergoing 4 months of regular aerobic training. Blood samples (10 mL) were collected monthly from 56 male subjects (17-19 years old). Creatine kinase and aspartate aminotransferase activities, total cholesterol, triglycerides, uric acid, C-reactive protein, alpha-1-acid glycoprotein, creatinine and urea concentrations were measured in sera using an Autolab Boehringer analyzer. Hemogram were obtained from total blood using KX-21 N SYSMEX equipment. The RCV values for leukocytes and all biochemical analytes were elevated compared to the literature values of sedentary subjects. On the other hand, the RCV values for red blood cell count were slightly lower in physically active than in sedentary individuals. Knowledge of analyte RCV values within physically active subjects should improve the sensitivity/specificity of the hematological and biochemical alterations induced by training or the use of recombinant form of erythropoietin through blood parameter analysis, particularly in cases of longitudinal monitoring. |
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Authors:
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Lázaro Alessandro S Nunes; René Brenzikofer; Denise Vaz de Macedo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-06 |
Journal Detail:
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Title: European journal of applied physiology Volume: 110 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 191-8 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Laboratório de Bioquímica do Exercício-LABEX, Instituto de Biologia, Universidade de Campinas-Unicamp, Cidade Universitária Zeferino Vaz, s/n, Barão Geraldo, Campinas, SP, CEP 13083-970, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aspartate Aminotransferases / blood Automation, Laboratory Biological Markers / blood* Blood Chemical Analysis / standards* C-Reactive Protein / metabolism Cholesterol / blood Creatine Kinase / blood Creatinine / blood Exercise* Hematologic Tests Humans Longitudinal Studies Male Orosomucoid / metabolism Reference Values Triglycerides / blood Urea / blood Uric Acid / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Orosomucoid; 0/Triglycerides; 57-13-6/Urea; 57-88-5/Cholesterol; 60-27-5/Creatinine; 69-93-2/Uric Acid; 9007-41-4/C-Reactive Protein; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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