| Reference values for 27 clinical chemistry tests in 70-year-old males and females. | |
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MedLine Citation:
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PMID: 19844080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reference values are usually defined based on blood samples from healthy men or nonpregnant women in the age range of 20-50 years. These values are not optimal for elderly patients, as many biological markers change over time and adequate reference values are important for correct clinical decisions. OBJECTIVE: To validate NORIP (Nordic Reference Interval Project) reference values in a 70-year-old population. METHODS: We studied 27 frequently used laboratory tests. The 2.5th and 97.5th percentiles for these markers were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. RESULTS: Reference values are reported for plasma alanine aminotransferase, albumin, alkaline phosphatase, pancreas amylase, apolipoprotein A1, apolipoprotein B, aspartate aminotransferase, bilirubin, calcium, chloride, cholesterol, creatinine, creatine kinase, C-reactive protein, glucose, gamma-glutamyltransferase, HDL-cholesterol, iron, lactate dehydrogenase, LDL-cholesterol, magnesium, phosphate, potassium, sodium, transferrin, triglycerides, urate and urea. CONCLUSION: Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance. Several of the reference interval limits were outside the 90% CI of a Scandinavian population (NORIP). |
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Authors:
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Lena Carlsson; Lars Lind; Anders Larsson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2009-10-21 |
Journal Detail:
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Title: Gerontology Volume: 56 ISSN: 1423-0003 ISO Abbreviation: Gerontology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7601655 Medline TA: Gerontology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 259-65 Citation Subset: IM |
Copyright Information:
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2009 S. Karger AG, Basel. |
Affiliation:
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Department of Medical Sciences, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Biological Markers / metabolism* Clinical Chemistry Tests* Cohort Studies Female Geriatric Assessment* Humans Male Reference Values Reproducibility of Results Sex Factors Sweden |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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