Document Detail

Reference Ranges for Lymphocyte Counts of Neonates: Associations Between Abnormal Counts and Outcomes.
MedLine Citation:
PMID:  22508916     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVE:Both high and low lymphocyte counts at birth have been associated with adverse outcomes. However, the validity of defining a lymphocyte count as "abnormal" depends on having an accurate reference range. We established a reference range for neonatal lymphocyte counts by using multihospital data and used this to assess previously reported relationships between abnormal counts and early onset sepsis (EOS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), periventricular leukomalacia, and birth asphyxia.METHODS:We first created a data set that excluded counts from neonates with diagnoses previously associated with abnormal lymphocyte counts. Then the complete data (counts excluded plus included in the reference range) were used to test associations between abnormal counts and EOS, IVH, ROP, periventricular leukomalacia, and outcomes after birth asphyxia.RESULTS:Lymphocyte counts were retrieved from 40 487 neonates, 10 860 of which were excluded from the reference range. A count >95th percentile was associated with EOS (2.07; 95% confidence interval [CI]: 1.80-2.38) and IVH ≥grade 3 (2.93; 95% CI: 1.83-4.71). A count <5th percentile was associated with EOS (odds ratio:1.24; 95% CI: 1.04-1.48), IVH ≥grade 3 (3.23; 95% CI: 1.95-5.36), and ROP ≥stage 3 (4.80: 95% CI: 2.38-9.66). Among 120 meeting criteria for birth asphyxia, those with a low count and a high nucleated red cell count had higher mortality (37% vs 11%, P = .001), more transfusions (P = .000), and more neurology referrals (P < .01).CONCLUSIONS:A reference range for lymphocytes can identify neonates with abnormal counts, which can be useful because these neonates are at higher risk for certain adverse outcomes.
Robert D Christensen; Vickie L Baer; Philip V Gordon; Erick Henry; Cody Whitaker; Robert L Andres; Sterling T Bennett
Related Documents :
7446526 - Rates of 47, + 13 amd 46 translocation d/13 patau syndrome in live births and compariso...
17327206 - Seasonality and the persistence and invasion of measles.
7602216 - Long-term effect of leprosy control in two prefectures of china, 1955-1993.
6980196 - International variation in the prevalence at birth of anencephalus in relation to mater...
3990146 - On the requirement of calcium, phosphorus and vitamin d by premature and low birthweigh...
21551396 - Maternal depressive symptomatology: 16-month follow-up of infant and maternal health-re...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-16
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aWomen and Newborn's Clinical Program, Intermountain Healthcare, Ogden, Utah;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Barriers to medication adherence in HIV-infected children and youth based on self- and caregiver rep...
Next Document:  Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolis...