| Refeeding hypophosphataemia is more common in enteral than parenteral feeding in adult in patients. | |
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MedLine Citation:
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PMID: 21256638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Refeeding hypophosphataemia (RH) can result in sudden death. This study aimed to compare the incidence of RH between patients fed enterally and those fed parenterally. METHODS: The risk of RH in adult patients fed parenterally (PN) or nasogastrically (NG) was assessed by comparison of patient records with the UK NICE guidelines for refeeding syndrome, between December 2007 and December 2008. A fall in serum phosphate to less than 0.6 mmol/L was indicative of RH. RESULTS: Of 321 patients,92 were at risk of RH. Of these, 23 (25%) patients developed RH (p = 0.003). 18 (33%) of NG fed, 'at-risk' patients developed RH vs 5 (13%) fed parenterally (p = 0.03). Death within 7 days and RH were not associated. The sensitivity and specificity of the NICE criteria for defining patient's risk of RH was calculated: 0.76 and 0.50 respectively for NG feeding; 0.73 and 0.38 respectively for parenteral feeding. CONCLUSION: Patients fed by NG tube and deemed at risk of RH are more likely to develop RH than patients fed by PN. The higher risk with NG feeding may be due to the incretin effect from absorption of glucose. The UK guidelines lack specificity. |
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Authors:
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Sebastian Zeki; Alison Culkin; Simon M Gabe; Jeremy M Nightingale |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2011-01-21 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 30 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-10-03 Revised Date: 2012-07-13 |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Lennard-Jones Intestinal Failure Unit, St. Mark's hospital, Harrow, Middlesex, UK. sebastiz@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Enteral Nutrition* / adverse effects Great Britain / epidemiology Humans Hypophosphatemia / epidemiology*, etiology Incidence Intubation, Gastrointestinal Medical Records Middle Aged National Health Programs Parenteral Nutrition* / adverse effects Phosphates / blood Practice Guidelines as Topic Refeeding Syndrome / blood*, epidemiology*, mortality, physiopathology Retrospective Studies Risk Factors Sensitivity and Specificity Water-Electrolyte Imbalance / etiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Phosphates |
| Comments/Corrections | |
Comment In:
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Clin Nutr. 2012 Jun;31(3):429; author reply 430
[PMID:
22154934
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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