Document Detail

Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease.
MedLine Citation:
PMID:  9795128     Owner:  NLM     Status:  MEDLINE    
A traditional view holds the belief that the behavioral effects of l-dihydroxyphenilalanine (l-DOPA) in Parkinsonian patients are achieved through the action of the newly produced dopamine (DA) on striatal DA receptors. In contrast to this view, recent studies in the rat model of Parkinson's disease point to the substantia nigra pars reticulata as an important target for the behavioral effects of l-DOPA. In the present study, we tested the contribution of the substantia nigra vs. that of the striatum, in the expression of contralateral turning induced by l-DOPA in rats with unilateral dopaminergic depletion. Rats turned contralaterally to the lesion in response to either intrastriatal or systemic l-DOPA administration. Injections of lidocaine into the denervated striatum substantially decreased, and occasionally completely abolished, the contralateral turning after systemic l-DOPA. These findings indicate that activation of the DA depleted striatum is both sufficient and essential for the expression of behavioral response after systemic administration of l-DOPA. The contribution of the substantia nigra to this behavioral response seems to depend to a great extent on an active striatal outflow.
A Mura; J Feldon; M Mintz
Related Documents :
41248 - Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo.
7666198 - Activation of dopamine cell firing by repeated l-dopa administration to dopamine-deplet...
1682018 - Multiple analysis of tyrosine hydroxylase and calmodulin distributions in the forebrain...
6504328 - Suppression of l-dopa-induced circling in rats with nigral lesions by blockade of centr...
1255578 - Acceleration of sexual maturation in female rats by male stimulation.
21886798 - Opiate sensitization induces fosb/Δfosb expression in prefrontal cortical, striatal and...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  808     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  48-55     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Behavioral Biology Laboratory, Institute of Toxicology, ETH, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiparkinson Agents / pharmacology*
Corpus Striatum / drug effects,  pathology,  physiopathology*
Levodopa / pharmacology*
Lidocaine / pharmacology
Motor Activity* / drug effects
Organ Specificity
Parkinson Disease, Secondary / chemically induced,  physiopathology*
Rats, Wistar
Stereotyped Behavior
Substantia Nigra / drug effects,  physiopathology*
Tyrosine 3-Monooxygenase / metabolism
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 1199-18-4/Oxidopamine; 137-58-6/Lidocaine; EC 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of gravity on vestibular neural development.
Next Document:  Evidence for the involvement of nitric oxide and nitric oxide synthase in the modulation of opioid-i...