Document Detail


Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease.
MedLine Citation:
PMID:  9795128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A traditional view holds the belief that the behavioral effects of l-dihydroxyphenilalanine (l-DOPA) in Parkinsonian patients are achieved through the action of the newly produced dopamine (DA) on striatal DA receptors. In contrast to this view, recent studies in the rat model of Parkinson's disease point to the substantia nigra pars reticulata as an important target for the behavioral effects of l-DOPA. In the present study, we tested the contribution of the substantia nigra vs. that of the striatum, in the expression of contralateral turning induced by l-DOPA in rats with unilateral dopaminergic depletion. Rats turned contralaterally to the lesion in response to either intrastriatal or systemic l-DOPA administration. Injections of lidocaine into the denervated striatum substantially decreased, and occasionally completely abolished, the contralateral turning after systemic l-DOPA. These findings indicate that activation of the DA depleted striatum is both sufficient and essential for the expression of behavioral response after systemic administration of l-DOPA. The contribution of the substantia nigra to this behavioral response seems to depend to a great extent on an active striatal outflow.
Authors:
A Mura; J Feldon; M Mintz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  808     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  48-55     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Affiliation:
Behavioral Biology Laboratory, Institute of Toxicology, ETH, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland. mura@toxi.biol.ethz.ch
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiparkinson Agents / pharmacology*
Corpus Striatum / drug effects,  pathology,  physiopathology*
Levodopa / pharmacology*
Lidocaine / pharmacology
Male
Motor Activity* / drug effects
Organ Specificity
Oxidopamine
Parkinson Disease, Secondary / chemically induced,  physiopathology*
Rats
Rats, Wistar
Stereotyped Behavior
Substantia Nigra / drug effects,  physiopathology*
Tyrosine 3-Monooxygenase / metabolism
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 1199-18-4/Oxidopamine; 137-58-6/Lidocaine; EC 1.14.16.2/Tyrosine 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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