Document Detail


Reevaluation of histomorphometric analysis of lung tissue in decision making for better patient selection for fontan-type operations.
MedLine Citation:
PMID:  15464501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The various types of cavopulmonary connection are occasionally unsuccessful even when the indications have been strictly fulfilled based on preoperative hemodynamic studies. We performed a detailed study of lung specimens from 60 patients who were judged to be candidates for the modified Fontan procedures based on a catheterizaton study in order to reevaluate the role of histologic studies of the pulmonary vasculature and to determine histologic criteria for the Fontan-type operation. METHODS: We performed a histomorphometric analysis of specimens from 53 biopsy and 7 autopsy cases (0.5 to 23 years of age), with single ventricle physiology. Twenty-eight cases were treated with a bidirectional Glenn shunt (BDGS) and 32 cases were treated by means of total cavopulmonary connections (TCPC) with or without fenestration, on the basis of the clinical and hemodynamic findings. To evaluate the medial thickness of small pulmonary arteries (SPAs), we used a measurement, D(R = 100 microm), that is unaffected by various degrees of vasoconstriction of the media or the age of the patients and that is representative of all SPAs in a section. Other variables, such as intimal lesions, SPA density, and the percentage of vessels containing a thrombus, were also measured. RESULTS: There was a significant difference in D(R = 100 microm) values between the BDGS cases with good and bad outcomes at p = 0.0007 (8.9 +/- 2.4 versus 13.4 +/- 1.9 microm), and the cutoff point for the success of BDGS was 13.7 microm. The same was true of the TCPC cases at p less than 0.0001 (8.4 +/- 1.7 versus 14.7 +/- 1.5 microm), and the cutoff point was 11.6 microm. There were no significant differences in other histomorphometric variables. Investigation of the relationship to hemodynamic data revealed a correlation between D(R = 100 microm) and mean pulmonary artery pressure at p = 0.028. There were no statistically significant correlations between other variables. CONCLUSIONS: The study revealed marked differences in D(R = 100 microm) values between patients with good and bad outcomes and provided D(R = 100 microm) cutoff points for BDGS and TCPC. In some cases, there were discrepancies between the results of the preoperative hemodynamic data and of the histomorphometric analysis; and because some patients were wrongly assessed based on clinical and hemodynamic criteria, histomorphometric study might be a useful method of supplementing the variety of clinical data used to determine the indications for this operation.
Authors:
Katsuhide Maeda; Shigeo Yamaki; Hideaki Kado; Toshihide Asou; Arata Murakami; Shinichi Takamoto
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  78     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1371-81; discussion 1371-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. maedak-tky@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autopsy
Biopsy
Child
Child, Preschool
Decision Making
Female
Fontan Procedure*
Heart Catheterization
Heart Defects, Congenital / pathology,  surgery*
Hemodynamics
Humans
Infant
Lung / blood supply,  pathology*
Male
Patient Selection*
Pulmonary Artery / pathology
Pulmonary Wedge Pressure
Retrospective Studies
Treatment Outcome
Tunica Media / ultrastructure
Vasoconstriction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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