| Reevaluation of digitalis efficacy. New light on an old leaf. | |
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MedLine Citation:
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PMID: 6375498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Use of digitalis for the treatment of patients with congestive heart failure and sinus rhythm remains controversial. To ascertain the proper therapeutic role of digitalis, we have critically appraised the published clinical evidence of digitalis efficacy using standardized methodologic criteria. A search of the English literature from 1960 to 1982 identified 736 articles, of which 16 specifically addressed the clinical evaluation of digitalis therapy for patients with congestive heart failure and sinus rhythm. Only two double-blind, placebo-controlled trials provided clinically useful information. One study showed that digoxin therapy could be withdrawn successfully in elderly patients with stable congestive heart failure. The other showed that patients with chronic heart failure and an S3 gallop benefited from digoxin therapy. |
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Authors:
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C D Mulrow; J R Feussner; R Velez |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Review |
Journal Detail:
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Title: Annals of internal medicine Volume: 101 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-07-17 Completed Date: 1984-07-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 113-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Digitalis* Digitalis Glycosides / administration & dosage, therapeutic use* Digoxin / therapeutic use Diuretics / therapeutic use Drug Therapy, Combination Heart Failure / drug therapy* Humans Plants, Medicinal* Plants, Toxic* Pulmonary Heart Disease / drug therapy Research Design |
| Chemical | |
Reg. No./Substance:
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0/Digitalis Glycosides; 0/Diuretics; 20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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