Document Detail

Reelin, lipoprotein receptors and synaptic plasticity.
MedLine Citation:
PMID:  17053810     Owner:  NLM     Status:  MEDLINE    
Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have recently been recognized as pivotal components of the neuronal signalling machinery. The interaction between APOE receptors and one of their ligands, reelin, allows them to function directly as signal transduction receptors at the plasma membrane to control not only neuronal positioning during brain development, but also synaptic plasticity in the adult brain. Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival.
Joachim Herz; Ying Chen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  7     ISSN:  1471-003X     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  850-9     Citation Subset:  IM    
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texus 75390, USA.
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MeSH Terms
Apolipoproteins E / genetics,  metabolism*
Brain / metabolism*,  ultrastructure
Brain Diseases / genetics,  metabolism,  physiopathology
Cell Adhesion Molecules, Neuronal / genetics,  metabolism*
Extracellular Matrix Proteins / genetics,  metabolism*
Nerve Tissue Proteins / genetics,  metabolism*
Neuronal Plasticity / physiology*
Receptors, Lipoprotein / genetics,  metabolism*
Receptors, N-Methyl-D-Aspartate / metabolism
Serine Endopeptidases / genetics,  metabolism*
Synaptic Membranes / metabolism,  ultrastructure
Synaptic Transmission / physiology
Reg. No./Substance:
0/Apolipoproteins E; 0/Cell Adhesion Molecules, Neuronal; 0/Extracellular Matrix Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Lipoprotein; 0/Receptors, N-Methyl-D-Aspartate; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/reelin protein

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