Document Detail


Reductively labile PRINT particles for the delivery of doxorubicin to HeLa cells.
MedLine Citation:
PMID:  18355010     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side length = 2 micron) containing 30 wt % of a disulfide-based cross-linker and 2 wt % doxorubicin were synthesized. This PRINT composition was shown to release doxorubicin in response to a reducing environment as measured by flow cytometry and was found to be highly proficient at killing HeLa cells in vitro.
Authors:
Robby A Petros; Patricia A Ropp; Joseph M DeSimone
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-03-20
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  130     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-05-16     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5008-9     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of North Carolina at Chapel Hill, Caudill Laboratories CB 3290, Chapel Hill, North Carolina 27599-3290, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Survival / drug effects
Doxorubicin / pharmacology*
Hela Cells
Humans
Microscopy, Electron, Scanning
Molecular Structure
Polymers / chemistry
Grant Support
ID/Acronym/Agency:
U54-CA119343/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Polymers; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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