Document Detail

Reductive and oxidative biosynthesis of plasmalogens in myelinating brain.
MedLine Citation:
PMID:  5501476     Owner:  NLM     Status:  MEDLINE    
Palmitic acid-1-(14)C and hexadecanol-1-(14)C were administered intracerebrally to 18-day-old rats. Incorporation of radioactivity into the constituent alkyl, alk-1-enyl, and 1-acyl moieties, as well as into the 2-acyl moieties, of the ethanolamine phosphatides of brain was determined after 1, 2, 3, 6, and 22 hr. Incorporation of radioactivity from hexadecanol into both alkyl ethers and alk-1-enyl ethers proceeded at a rate more than 10 times higher than from palmitic acid. Hexadecanol was rapidly oxidized to fatty acids which were incorporated into the acyl moieties of the ethanolamine phosphatides. When palmitic acid was used as a precursor, labeled long-chain alcohols could be isolated from the lipid extract. As labeled long-chain aldehydes could not be detected in any of the lipid extracts, alcohols appear to be key intermediates for the biosynthesis of both alkyl and alk-1-enyl glycerophosphatides.
H H Schmid; T Takahashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  11     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1971-04-13     Completed Date:  1971-04-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  412-9     Citation Subset:  IM    
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MeSH Terms
Alcohols / biosynthesis,  metabolism
Aldehydes / biosynthesis
Brain / metabolism*
Carbon Isotopes
Chemical Phenomena
Chromatography, Gas
Chromatography, Thin Layer
Lipids / analysis
Palmitic Acids / metabolism
Phosphatidylethanolamines / analysis
Plasmalogens / biosynthesis*
Reg. No./Substance:
0/Alcohols; 0/Aldehydes; 0/Carbon Isotopes; 0/Lipids; 0/Palmitic Acids; 0/Phosphatidylethanolamines; 0/Plasmalogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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