Document Detail

Reduction of urinary 1-hydroxypyrene excretion in coke-oven workers exposed to polycyclic aromatic hydrocarbons due to improved hygienic skin protective measures.
MedLine Citation:
PMID:  8048786     Owner:  NLM     Status:  MEDLINE    
The effect of hygienic skin protective measures on the internal exposure to polycyclic aromatic hydrocarbons (PAHs) was studied in 13 coke-oven workers. The study took place over 2 consecutive weeks. In 1 week the subjects worked under the normal circumstances, in the other week extra hygienic skin protective measures were instituted: laundered working clothes and a new pair of gloves before each 8-h work shift, and the washing both of the hands and of the face before each break. Biological monitoring was undertaken to measure the effect of the extra hygienic measures on the urinary 1-hydroxypyrene excretion, which is a measure of the internal PAH exposure. The increase of the urinary 1-hydroxypyrene concentration over the 4-day workweek was on average 37% lower when extra hygienic measures were taken, being 1.3 instead of 2.3 mumole 1-hydroxypyrene per mole creatinine (P = 0.03, N = 13). This study demonstrates that simple hygienic skin protective measures result in a significant reduction of the internal PAH exposure.
J G VanRooij; M M Bodelier-Bade; P M Hopmans; F J Jongeneelen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of occupational hygiene     Volume:  38     ISSN:  0003-4878     ISO Abbreviation:  Ann Occup Hyg     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203526     Medline TA:  Ann Occup Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-56     Citation Subset:  IM    
Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands.
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MeSH Terms
Air Pollutants, Occupational / urine*
Analysis of Variance
Biological Markers / urine
Chemical Industry
Gloves, Protective
Mutagens / analysis*
Occupational Exposure / prevention & control*
Polycyclic Compounds / pharmacokinetics*
Pyrenes / analysis*
Skin Absorption
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Biological Markers; 0/Coke; 0/Mutagens; 0/Polycyclic Compounds; 0/Pyrenes; 5315-79-7/1-hydroxypyrene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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