Document Detail

Reduction of thromboxane A2 synthesis in pregnancy by polyunsaturated fatty acid supplements.
MedLine Citation:
PMID:  8420313     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: High-dose supplements of fish oil reduce thromboxane synthesis in nonpregnant human subjects and were therefore proposed as a means of preventing various small-vessel disorders, including preeclampsia. The effect of fish oil on thromboxane metabolism in pregnancy was investigated in our study. STUDY DESIGN: Sixteen normal pregnant women in the third trimester of pregnancy were treated with a daily ingestion of 6 gm fish oil capsules containing 1.6 gm of n-3 fatty acid. In five patients the treatment was stopped because of severe-flavored reflux and hiccups. Eleven patients completed 3 weeks of treatment. Twenty-four-hour urinary 11-dehydro-thromboxane B2 was measured by means of radioimmunoassay before and after completion of the study protocol in these 11 patients and in seven control pregnant women who did not receive the oil treatment. RESULTS: A decrease ranging from 32% to 71%, in 24-hour urinary 11-dehydro-thromboxane B2 excretion (mean reduction from 1606 pg/mg creatinine to 779 pg/mg creatinine, p < 0.001) was found among the 11 fish oil-treated women. No change in excretion was found among the control women. No maternal, fetal, or neonatal bleeding disturbances occurred, and no laboratory changes in coagulation markers were observed. CONCLUSIONS: High-dose n-3 fatty acid intake in pregnancy significantly reduces maternal thromboxane A2 synthesis. These results may provide a basis for a possible role of fish oil in managing patients at risk for preeclampsia.
E Schiff; G Ben-Baruch; G Barkai; E Peleg; T Rosenthal; S Mashiach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel.
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MeSH Terms
Creatinine / blood
Fatty Acids, Omega-3 / administration & dosage
Fetal Growth Retardation / prevention & control*
Fish Oils / administration & dosage*
Pregnancy Complications, Cardiovascular / prevention & control*
Pregnancy Trimester, Third
Thromboxane A2 / biosynthesis*
Thromboxane B2 / analogs & derivatives*,  urine
Urea / blood
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fish Oils; 54397-85-2/Thromboxane B2; 57-13-6/Urea; 57576-52-0/Thromboxane A2; 60-27-5/Creatinine; 67910-12-7/11-dehydro-thromboxane B2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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