Document Detail


Reduction of syndecan-1 expression is associated with dysplastic oral epithelium.
MedLine Citation:
PMID:  10947246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Syndecans are a family of integral membrane proteoglycans that participate in cell-matrix interactions and growth factor binding. Syndecan-1 expression is induced during keratinocyte differentiation and reduced in squamous cell carcinomas. The purpose of this study was to examine the alteration in syndecan-1 expression in dysplastic oral epithelium. Sixty-six oral biopsy specimens (43 epithelial dysplasias, 3 carcinoma in situ and 20 squamous cell carcinomas) were studied using immunohistochemical methods. The normal epithelium specimens were highly positive for syndecan-1. Fifteen of 46 dysplasias or carcinoma in situ specimens showed negative or weak staining for syndecan-1, two of which were totally negative. Intermediate and strong staining were observed in 17 and 14 dysplasias or carcinoma in situ specimens, respectively. Thirteen (65%) squamous cell carcinomas showed negative or weak staining for syndecan-1, seven of which were totally negative. Only three carcinomas had a strong syndecan-1 expression. Four of the 34 patients with dysplasia who were followed up developed squamous cell carcinoma. All these dysplasias had weak or totally negative syndecan-1 expression. The results suggest that the loss of syndecan-1 is associated with dysplastic changes in oral epithelium.
Authors:
T Soukka; J Pohjola; P Inki; R P Happonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  29     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Carcinoma in Situ / metabolism*
Carcinoma, Squamous Cell / metabolism*
Cell Transformation, Neoplastic / metabolism*
Down-Regulation
Epithelial Cells / metabolism,  pathology*
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Male
Membrane Glycoproteins / biosynthesis*
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / metabolism*
Precancerous Conditions / metabolism*
Proteoglycans / biosynthesis*
Syndecan-1
Syndecans
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Membrane Glycoproteins; 0/Proteoglycans; 0/SDC1 protein, human; 0/Syndecan-1; 0/Syndecans; 0/Tumor Markers, Biological

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