| Reduction of stenosis due to intimal hyperplasia after stent supported angioplasty of peripheral arteries by local administration of paclitaxel in swine. | |
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MedLine Citation:
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PMID: 17620941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess if local intra-arterial administration of paclitaxel using drug-coated balloons or an admixture of paclitaxel to contrast medium inhibits stenosis after percutanous transluminal angioplasty (PTA) of peripheral arteries in a porcine overstretch model. METHODS: Neointimal proliferation and stenosis were induced by overstretch and stenting of 40 peripheral arteries in 20 pigs. Paclitaxel was administered locally during PTA using coated balloons (n = 20) or dissolved in contrast medium (n = 10). Conventional balloons and contrast medium were used in a control group (n = 10). Reangiography with quantitative analysis was performed after 5 weeks. RESULTS: On reangiography diameter stenosis and late lumen loss were significantly reduced by both methods of local drug delivery compared with control group; minimal luminal diameter was significantly larger in the treatment groups. CONCLUSIONS: Local short-term administration of paclitaxel during PTA of peripheral arteries using balloons or contrast medium as drug carriers reduced stenosis due to intimal hyperplasia. |
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Authors:
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Thomas Albrecht; Ulrich Speck; Claudia Baier; Karl-Jürgen Wolf; Michael Böhm; Bruno Scheller |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 42 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-10 Completed Date: 2007-11-07 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 579-85 Citation Subset: IM |
Affiliation:
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Department of Radiology and Nuclear Medicine, Campus Benjamin Franklin, Charité, Free University und Humboldt University Berlin, Berlin, Germany. thomas.albrecht@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography
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methods* Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects Animals Constriction, Pathologic / prevention & control* Infusions, Intra-Arterial Male Paclitaxel / administration & dosage, pharmacology* Peripheral Vascular Diseases / physiopathology*, radiography* Stents* Swine Tunica Intima / drug effects* |
| Chemical | |
Reg. No./Substance:
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33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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