Document Detail

Reduction of sodium dependent stump currents disturbs urodele limb regeneration.
MedLine Citation:
PMID:  490133     Owner:  NLM     Status:  MEDLINE    
We have asked the question whether the natural electric currents which leave urodele limb stumps are in any way needed for their regeneration. As an initial test, we have greatly reduced such currents in the tiger salamander, Ambystoma tigrinum, by applying 0.5 mM amiloride to the stump skin or by immersion of the animals in sodium depleted media. We have also reduced such currents in the red spotted newt, Notophthalmus viridescens, by such immersion. Limb regeneration in half of the amiloride-treated animals was either entirely blocked or grossly deficient, while the others regenerated normally. Limb regeneration in sodium depleted media was consistently inhibited for some weeks but then recovered. These results are consistent with the hypothesis that stump currents are in some way needed for normal regeneration.
R B Borgens; J W Vanable; L F Jaffe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  209     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  377-86     Citation Subset:  IM    
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MeSH Terms
Ambystoma / physiology*
Amiloride / pharmacology
Forelimb / physiology
Membrane Potentials*
Regeneration* / drug effects
Salamandridae / physiology*
Sodium / pharmacology*
Time Factors
Urodela / physiology*
Reg. No./Substance:
2609-46-3/Amiloride; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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