| Reduction of sodium dependent stump currents disturbs urodele limb regeneration. | |
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MedLine Citation:
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PMID: 490133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have asked the question whether the natural electric currents which leave urodele limb stumps are in any way needed for their regeneration. As an initial test, we have greatly reduced such currents in the tiger salamander, Ambystoma tigrinum, by applying 0.5 mM amiloride to the stump skin or by immersion of the animals in sodium depleted media. We have also reduced such currents in the red spotted newt, Notophthalmus viridescens, by such immersion. Limb regeneration in half of the amiloride-treated animals was either entirely blocked or grossly deficient, while the others regenerated normally. Limb regeneration in sodium depleted media was consistently inhibited for some weeks but then recovered. These results are consistent with the hypothesis that stump currents are in some way needed for normal regeneration. |
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Authors:
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R B Borgens; J W Vanable; L F Jaffe |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of experimental zoology Volume: 209 ISSN: 0022-104X ISO Abbreviation: J. Exp. Zool. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1979-12-29 Completed Date: 1979-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375365 Medline TA: J Exp Zool Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 377-86 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ambystoma
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physiology* Amiloride / pharmacology Animals Female Forelimb / physiology Male Membrane Potentials* Regeneration* / drug effects Salamandridae / physiology* Sodium / pharmacology* Time Factors Urodela / physiology* |
| Chemical | |
Reg. No./Substance:
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2609-46-3/Amiloride; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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