Document Detail


Reduction of side effects by combining clozapine with amisulpride: case report and short review of clozapine-induced hypersalivation-a case report.
MedLine Citation:
PMID:  15706466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Side effects from a high-dose clozapine treatment for a schizophrenic patient led to massive compliance problems. The dose of clozapine could be halved without recurrence of an acute psychotic symptomatology by concomitantly administering amisulpride. The side effects, especially hypersalivation, disappeared almost entirely, which in turn led to good compliance. In a short review we would like to present the pathophysiology and therapeutic options of clozapine-induced hypersalivation.
Authors:
B Croissant; D Hermann; R Olbrich
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Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  38     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-11     Completed Date:  2005-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  38-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / administration & dosage,  adverse effects*,  therapeutic use
Clozapine / administration & dosage,  adverse effects*,  therapeutic use
Drug Therapy, Combination
Humans
Male
Schizophrenia, Paranoid / drug therapy,  psychology
Sialorrhea / chemically induced*
Sulpiride / administration & dosage,  adverse effects*,  analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 15676-16-1/Sulpiride; 53583-79-2/sultopride; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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