| Reduction of serum lipids by soy protein and soluble fiber is not associated with the ABCG5/G8, apolipoprotein E, and apolipoprotein A1 polymorphisms in a group of hyperlipidemic Mexican subjects. | |
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MedLine Citation:
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PMID: 19917453 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Several studies have evaluated the effect of soy protein or soluble fiber on serum cholesterol in hypercholesterolemic subjects, with different results. We hypothesized that this response is associated with the presence of polymorphisms in genes encoding proteins involved in lipoprotein metabolism or reverse cholesterol transport. Thus, the aims of the present work were to study the effectiveness of a dietary portfolio consisting of a combination of soy protein and soluble fiber integrated in a low saturated fat (LSF) diet on blood lipids in a Mexican group with hyperlipidemia and to determine the association between responsiveness to the diet and the frequency of apolipoprotein (Apo) E and ApoA1 and ABCG5/8 polymorphisms. Forty-three hyperlipidemic subjects (20 men and 23 women) were given an LSF diet for 1 month, followed by an LSF diet that included 25 g of soy protein and 15 g of soluble fiber daily for 2 months. After the 3-month dietary intervention, serum total cholesterol (TC) significantly decreased by 20.6%, and serum triglycerides (TGs) decreased by 40.4%. Fifty-one percent of the subjects had a reduction more than 20% in serum TC, and 77% of the subjects had a reduction more than 20% in serum TG (hyperresponders). Approximately 14% of the hypercholesterolemic subjects had the ABCG8 (52 G/C) polymorphism, 65% had the ABCG5 (1950 C/G and G/G) polymorphism, 53.5% had the ApoA1 (-75 G/A and A/A) polymorphism, and 23.3% had the ApoE (3/4) polymorphism. Independently of genotype, the combination of cholesterol-lowering foods in an LSF diet significantly reduced serum TC and TG in Mexican hypercholesterolemic subjects. |
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Authors:
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Nimbe Torres; Martha Guevara-Cruz; Julio Granados; Gilberto Vargas-Alarcón; Berenice González-Palacios; Victoria E Ramos-Barragan; Gabriela Quiroz-Olguín; Isabel M Flores-Islas; Armando R Tovar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 29 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 728-35 Citation Subset: IM |
Affiliation:
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Depto de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, México. nimbester@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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