Document Detail

Reduction of the risk of rheumatoid arthritis among women who take oral contraceptives.
MedLine Citation:
PMID:  2306289     Owner:  NLM     Status:  MEDLINE    
Discrepant results among investigations of the association between oral contraceptive use and rheumatoid arthritis (RA) have been ascribed to shortcomings in the study methods. In the present study, we obtained detailed information on oral contraceptive use in 135 young women with confirmed definite or classic RA of recent onset and in 378 controls with soft tissue rheumatism or osteoarthritis. All patients had at least 2 years of followup to confirm the consistency of the diagnosis. Oral contraceptive use at any time before disease onset was reported by 70% of the RA patients and 85% of the controls; the latter figure corresponded to general population data for The Netherlands. This yielded a relative risk for RA of 0.39 among those who had ever used oral contraceptives and 0.58 for those using oral contraceptives at the time of symptom onset. The preventive effect of oral contraceptive use on the risk of RA was found to be independent of the dose, duration of use, or presence of HLA-DR4. The strongest protection was seen in women with a family history of RA and in women ages 31-40 at symptom onset. The conflicting results in the literature are discussed, and a possible biologic mechanism for this phenomenon is suggested.
J M Hazes; B C Dijkmans; J P Vandenbroucke; R R de Vries; A Cats
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  33     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-23     Completed Date:  1990-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  AIM; IM; J    
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Age Factors
Arthritis, Rheumatoid / etiology*,  genetics
Contraceptives, Oral / pharmacology*
HLA-DR4 Antigen / analysis
Middle Aged
Risk Factors
Reg. No./Substance:
0/Contraceptives, Oral; 0/HLA-DR4 Antigen
Comment In:
Arthritis Rheum. 1991 Apr;34(4):498-9   [PMID:  2064648 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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