Document Detail

Reduction of renal function in exercising horses.
MedLine Citation:
PMID:  11093625     Owner:  NLM     Status:  MEDLINE    
Glomerular filtration rate (GFR) and extracellular volume (ECFV) were measured before, during and after treadmill exercise in 5 trained Thoroughbred horses (mean weight 483 kg). GFR/ECFV was determined by plasma disappearance of Tc-DTPA and ECFV was measured independently as thiocyanate space. Resting GFR averaged 1.6 l/min (3.3 ml/kg/min) and fell by over 40% during exercise, moreover the fall was severe even during the first walk, prior to trotting. The results suggest that rather than being protected, GFR is allowed to fall, even with mild exercise and that this is probably an adaptation to allow greater perfusion of muscle and skin. In man, GFR appears to be more resistant to the effects of exercise but it is hard to compare intensity of exercise between such different species.
A Gleadhill; D Marlin; P A Harris; A R Michell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  32     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-01-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  509-14     Citation Subset:  IM    
Animal Health Trust, Newmarket, Suffolk, UK.
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MeSH Terms
Exercise Test / veterinary
Extracellular Space
Glomerular Filtration Rate / veterinary
Horses / physiology*
Kidney / physiology*
Physical Conditioning, Animal / physiology*
Technetium Tc 99m Pentetate / pharmacokinetics
Reg. No./Substance:
65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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