Document Detail

Reduction of pupillary constriction during cataract surgery using suprofen.
MedLine Citation:
PMID:  3513744     Owner:  NLM     Status:  MEDLINE    
The efficacy of a new nonsteroidal anti-inflammatory agent, suprofen, for reducing pupillary constriction during cataract surgery was ascertained in a double-masked, multicenter, clinical study. Prior to surgery 1.0% suprofen or a placebo was instilled; the surgeon's normal regimen of mydriatics and cycloplegics was used. Suprofen (209 patients) was far more effective than the placebo (203 patients) in maintaining a dilated pupil prior to intraocular lens (IOL) implantation (or instillation of a miotic). The mean pupillary area prior to IOL implantation was 6.3 sq mm larger (20% larger) in patients treated with suprofen than in patients receiving the placebo. The investigators' subjective evaluations of the adequacy of pupil size for IOL implantation and of the difficulty of IOL implantation favored patients treated with suprofen over those receiving the placebo.
W J Stark; W R Fagadau; R H Stewart; A S Crandall; J M deFaller; T A Reaves; P E Klein
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  104     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-16     Completed Date:  1986-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cataract Extraction*
Clinical Trials as Topic
Lenses, Intraocular
Middle Aged
Mydriatics / pharmacology
Phenylpropionates / pharmacology*
Pupil / drug effects*
Random Allocation
Suprofen / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Mydriatics; 0/Phenylpropionates; 40828-46-4/Suprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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