Document Detail

Reduction of pulmonary capillary blood volume following cold exposure in patients with Raynaud's phenomenon.
MedLine Citation:
PMID:  3191759     Owner:  NLM     Status:  MEDLINE    
In a previous study we induced digital vasospasm with cold pressor stimulus, and an acute decrease in the lung diffusing capacity for carbon monoxide (Dsb) resulted. We hypothesized its cause to be spasm occurring simultaneously in the pulmonary vasculature and the digital arteries. We measured in this study the Dsb, the diffusing capacity of the pulmonary membrane (Dm), and the volume of blood in the pulmonary capillaries (Vc) after cold-induced digital vasospasm in patients with Raynaud's phenomenon. Control subjects showed no significant decrease in Dsb, Dm, or Vc after cold exposure. Eight of 12 subjects with Raynaud's phenomenon had a significant decrease in Dsb 60 min after testing (25.3 +/- 6.6 vs 19.8 +/- 6.1 ml/min/mm Hg, p less than 0.01). The acute decrease in Dsb was due to a significant decrease in Vc (54 +/- 20 vs 39 +/- 10 ml, p less than 0.05), while Dm was unchanged (52 +/- 17 vs 51 +/- 20 ml/min). Four subjects who had a decrease in Dsb after cold challenge had repeated studies later after pretreatment with sublingual nifedipine. The magnitude of change in Dsb was similar to that observed in the untreated state (23.6 +/- 10.6 vs 20.9 +/- 9.6 ml/min/mm Hg). We conclude that digital vasospasm is accompanied by an acute reduction in Vc in both primary and secondary Raynaud's phenomenon and indicates concurrent vasoconstriction within the pulmonary vaculature.
W G Barr; P J Fahey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  94     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-12     Completed Date:  1989-01-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1195-9     Citation Subset:  AIM; IM    
Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL.
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MeSH Terms
Blood Volume*
Carbon Monoxide / metabolism
Cold Temperature / adverse effects*
Fingers / blood supply
Lung / blood supply*,  metabolism
Lung Volume Measurements
Middle Aged
Nifedipine / pharmacology
Raynaud Disease / metabolism,  physiopathology*
Vasomotor System / physiopathology
Reg. No./Substance:
21829-25-4/Nifedipine; 630-08-0/Carbon Monoxide

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