| Reduction of proliferative heterogeneity of CHEF18 Chinese hamster cell line during the progression toward tumorigenicity. | |
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MedLine Citation:
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PMID: 1757399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Doubling time and generation time represent two parameters by which the proliferation of cultured mammalian cells can be monitored. In this study we report the characterization of CHEF18 Chinese hamster cell line during the progression toward tumorigenicity by analysis of doubling time and generation time. The two parameters reveal that the proliferation was initially different, indicating the presence of a proliferative heterogeneity among the cycling cells. The progressive reduction up to the disappearance of this discrepancy suggests that a modification of the length of some phases of the cell cycle may have occurred during the progression toward tumorigenicity. However, the hypothesis that the shortening of doubling time might be due to a continuous coming out of cells from the cell cycle rather than to a shortening of the cell cycle is presented. |
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Authors:
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G Rainaldi; B Pinto; A Piras; L Vatteroni; S Simi; L Citti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: In vitro cellular & developmental biology : journal of the Tissue Culture Association Volume: 27A ISSN: 0883-8364 ISO Abbreviation: In Vitro Cell. Dev. Biol. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-02-05 Completed Date: 1992-02-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8506951 Medline TA: In Vitro Cell Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 949-52 Citation Subset: IM |
Affiliation:
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Genetica e Biochimica Tossicologica, Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / physiology Cell Transformation, Neoplastic / genetics, pathology* Cricetinae Cricetulus Fibroblasts / cytology*, physiology Fluorescent Antibody Technique G1 Phase Genetic Variation / genetics Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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