Document Detail


Reduction of postmolar gestational trophoblastic neoplasia by early diagnosis and treatment.
MedLine Citation:
PMID:  19370899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare contemporary and historical clinical presentation of complete moles (CMs) and the rates of gestational trophoblastic neoplasia (GTN). STUDY DESIGN: A study was conducted of a current cohort of 108 consecutive cases of CM from 3 medical centers in Israel accrued during a 5-year period and 87 CM cases reported by the New England Trophoblastic Disease Center (NETDC) from the years 1988 to 1993. Clinical presentation and the rate of GTN of our cohort of CM and cases from the NETDC were compared. RESULTS: Fewer current CMs presented with vaginal bleeding than historic NETDC cases (52% vs. 84%, p <0.001, respectively), and a greater proportion of current patients with CM were referred to termination of the pregnancy due solely to ultrasonographic findings (38% vs. 9%, p < 0.001, respectively). GTN rates were significantly lower in the current patients with CM compared to NETDC controls (14% vs. 23%, p<0.05, respectively). CONCLUSION: First-trimester ultrasound examination leads to early diagnosis of molar and of nonviable pregnancies subsequently histologically diagnosed as CM. The early evacuation of the molar pregnancy is associated with a reduction in the rate of GTN.
Authors:
Alon Ben-Arie; Hagit Deutsch; Vania Volach; Gil Peer; Monica Husar; Ofer Lavie; Ofer Gemer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  54     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Abortion, Therapeutic
Adolescent
Adult
Female
Gestational Trophoblastic Neoplasms / diagnosis,  prevention & control*,  ultrasonography*
Humans
Hydatidiform Mole / diagnosis,  prevention & control,  ultrasonography*
Middle Aged
Pregnancy
Pregnancy Trimester, First
Sensitivity and Specificity
Ultrasonography, Prenatal / methods*,  standards
Uterine Neoplasms / diagnosis,  prevention & control*,  ultrasonography*
Young Adult

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