Document Detail

Reduction of plasma catecholamines in humans during clinically controlled severe underfeeding.
MedLine Citation:
PMID:  10656837     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sympathetic hyperactivity is one factor for alterations encountered in the plurimetabolic syndrome, a cluster of metabolic abnormalities including obesity, hyperlipidemia, sometimes hyperglycaemia, and hypertonia. It was interesting to know if prolonged severe underfeeding (230 kcal/day) leads to decreases in catecholamines in those patients. METHODS: The plasma concentrations of catecholamines in patients (n = 16) suffering from plurimetabolic syndrome were studied before and during a 16-day period of medically controlled severe underfeeding (230 kcal/day) at rest and in response to exercise. RESULTS: During the period of underfeeding, mean norepinephrine concentrations decreased at rest from 1.45 to 0. 96 nmol/liter, and in response to exercise, from 6.1 to 3.2 nmol/liter. Epinephrine concentrations decreased from 0.15 to 0.1 nmol/liter and from 0.26 to 0.17 nmol/liter, respectively. A significant decrease in catecholamine concentrations was observed only after 16 days of underfeeding. CONCLUSIONS: Clinically controlled underfeeding of patients with plurimetabolic syndrome may result in beneficial clinical and biochemical effects. The findings indicate that relatively long periods of underfeeding induce decreases in plasma catecholamine concentrations. Nevertheless, most of the fall in mean values in norepinephrine and also of the fall in blood pressure values occurred by Day 2. From those tendencies and from the significant changes in both parameters at Day 16 of severe underfeeding one could conclude that altered sympathetic nervous system activity could contribute to the fall in blood pressure.
L Göhler; T Hahnemann; N Michael; P Oehme; H D Steglich; E Conradi; T Grune; W G Siems
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Preventive medicine     Volume:  30     ISSN:  0091-7435     ISO Abbreviation:  Prev Med     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-14     Completed Date:  2000-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Copyright Information:
Copyright 2000 American Health Foundation and Academic Press.
Clinics of Physical Medicine and Rehabilitation, University Hospital Charité, Humboldt University, Berlin, Germany.
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MeSH Terms
Blood Pressure / physiology
Energy Intake / physiology
Epinephrine / blood*
Exercise Test
Fasting / physiology*
Hyperlipidemias / diet therapy,  physiopathology*
Hypertension / physiopathology,  therapy
Insulin Resistance / physiology*
Middle Aged
Norepinephrine / blood*
Obesity / diet therapy,  physiopathology*
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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