Document Detail

Reduction of perioperative hemorrhage by anterior mediastinal spray application of fibrin glue during cardiac operations.
MedLine Citation:
PMID:  2445314     Owner:  NLM     Status:  MEDLINE    
A variety of published techniques for the production of concentrated fibrinogen from units of screened single-donor human plasma have led to increasing clinical use of fibrin glue in the United States. We have adapted a method of applying this material with a disposable plastic sprayer. In 20 consecutively treated patients, fibrin glue was sprayed on the anterior mediastinum before closure of the median sternotomy incision. A control group of 20 patients undergoing the identical cardiac operations (13 coronary artery bypass grafting procedures [CABG], 4 valve replacements [including 1 reoperative procedure], and 3 combined valve replacements and CABG) by the same surgeon within a one-year period was chosen for comparison of chest tube outputs. Specifically, chest tube outputs were as follows for treated and untreated patients, respectively: at 12 hours, 461 +/- 40 ml (mean +/- 1 standard error of the mean versus 731 +/- 80 ml; at 24 hours, 714 +/- 73 ml versus 1,016 +/- 109 ml; and at 48 hours, 863 +/- 93 ml versus 1,187 +/- 137 ml. The differences between control and spray chest tube output are statistically significant by unpaired t test (p less than 0.05) at both 12 and 24 hours. Thus, this method can reduce perioperative hemorrhage from the anterior mediastinum after cardiac operations.
W D Spotnitz; M S Dalton; J W Baker; S P Nolan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  44     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-14     Completed Date:  1987-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-31     Citation Subset:  AIM; IM    
Department of Surgery, University of Virginia Medical Center, Charlottesville 22908.
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MeSH Terms
Aprotinin / administration & dosage*
Cardiac Surgical Procedures*
Drug Combinations / administration & dosage
Factor XIII / administration & dosage*
Fibrin Tissue Adhesive
Fibrinogen / administration & dosage*
Hemostasis, Surgical / methods*
Postoperative Complications / prevention & control
Thrombin / administration & dosage*
Tissue Adhesives / administration & dosage*
Reg. No./Substance:
0/Aerosols; 0/Drug Combinations; 0/Fibrin Tissue Adhesive; 0/Tissue Adhesives; 9001-32-5/Fibrinogen; 9013-56-3/Factor XIII; 9087-70-1/Aprotinin; EC

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