Document Detail

Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia.
MedLine Citation:
PMID:  10616629     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There have been many studies reporting reduced volume of the hippocampus or other limbic structures in patients with schizophrenia, but the literature is inconsistent. AIMS: To compare patients with either first-episode or chronic schizophrenia with controls using high-resolution volumetric magnetic resonance imaging (MRI) scans. METHOD: Thirteen patients with first-episode schizophrenia, 27 with chronic schizophrenia and 31 controls had 1.5 mm coronal slices taken through the whole brain using a spoiled-grass MRI acquisition protocol. RESULTS: The parahippocampal gyrus was reduced significantly on the left side in patients with chronic schizophrenia compared with controls for both male and female patients, whereas the hippocampus was reduced significantly on both sides only in female patients. There were no significant reductions in any structure between patients with first-episode schizophrenia and controls. CONCLUSIONS: Volumetric reduction seen in patients with chronic schizophrenia may be due to an active degenerative process occurring after the onset of illness.
K Razi; K P Greene; M Sakuma; S Ge; M Kushner; L E DeLisi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  174     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  512-9     Citation Subset:  IM    
Department of Psychiatry, SUNY, Stony Brook 11794, USA.
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MeSH Terms
Analysis of Variance
Brain Diseases / pathology*
Hippocampus / pathology*
Magnetic Resonance Imaging / methods
Schizophrenia / pathology*
Grant Support
R0I-44233//PHS HHS
Comment In:
Br J Psychiatry. 1999 Oct;175:388-9   [PMID:  10789308 ]

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