| Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid. | |
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MedLine Citation:
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PMID: 16081267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress is one of the major risk factors for coronary artery disease. Ellagic acid is a phenolic compound present in fruits and nuts, and has been found to have antioxidative property. Twenty-four New Zealand white (NZW) rabbits were assigned randomly into four dietary groups. The normal group was fed regular rabbit chow, and the cholesterol group was fed a high fat and cholesterol diet. The ellagic acid (E) group and probucol group were fed the same diet as the cholesterol group plus the addition of 1% (w/w diet) ellagic acid and probucol, respectively. Oxidative stress [as measured by plasma lipids, oxygen free radicals and thiobarbituric acid reactive substances (TBARS)] increased in the cholesterol group compared with the normal group; however, it decreased in the probucol and E groups compared with the cholesterol group. Forty-five percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the cholesterol group, but only 2-3% was covered in the E and probucol groups. The aortic level of 8-(OH)dG and the expression of caspase-8, caspase-9 and Fas ligand were also suppressed after ellagic acid supplement. These results indicated that ellagic acid could prevent atherosclerosis via suppression of oxidative stress and apoptosis in hyperlipidemic rabbits. |
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Authors:
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Ya-Mei Yu; Weng-Cheng Chang; Chieh-Hsi Wu; Su-Yin Chiang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-08-02 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 16 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-20 Completed Date: 2005-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 675-81 Citation Subset: IM |
Affiliation:
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Department of Nutrition, China Medical University, Taichung, Taiwan. yuyamei@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology Antioxidants / pharmacology Aorta, Thoracic / pathology Apoptosis / drug effects* Atherosclerosis / prevention & control Caspase 8 Caspase 9 Caspases / metabolism Deoxyguanosine / analogs & derivatives, metabolism Ellagic Acid / pharmacology* Fas Ligand Protein Free Radical Scavengers / metabolism Hyperlipidemias / drug therapy*, metabolism, pathology Lipids / blood Membrane Glycoproteins / metabolism Oxidative Stress / drug effects* Probucol / pharmacology Rabbits Thiobarbituric Acid Reactive Substances / metabolism Tumor Necrosis Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/8-hydroxy-2'-deoxyguanosine; 0/Anticholesteremic Agents; 0/Antioxidants; 0/Fas Ligand Protein; 0/Free Radical Scavengers; 0/Lipids; 0/Membrane Glycoproteins; 0/Thiobarbituric Acid Reactive Substances; 0/Tumor Necrosis Factors; 23288-49-5/Probucol; 476-66-4/Ellagic Acid; 961-07-9/Deoxyguanosine; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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