| Reduction of new coronary events and new atherothrombotic brain infarction in older persons with diabetes mellitus, prior myocardial infarction, and serum low-density lipoprotein cholesterol >/=125 mg/dl treated with statins. | |
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MedLine Citation:
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PMID: 12403804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of >/=125 mg/dl treated with statins and with no lipid-lowering drug. METHODS: The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 +/- 9 years, with prior myocardial infarction and a serum LDL cholesterol of >/=125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 +/- 18 months. RESULTS: At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. CONCLUSIONS: Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of >/=125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins. |
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Authors:
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Wilbert S Aronow; Chul Ahn; Hal Gutstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 57 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-29 Completed Date: 2002-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: M747-50 Citation Subset: AIM; IM |
Affiliation:
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Cardiology Division, Department of Medicine,Westchester Medical Center/New York Medical College, Valhalla, USA. WSAronow@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebral Infarction / prevention & control* Cholesterol, LDL / blood* Diabetes Complications* Diabetes Mellitus / blood Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / complications, drug therapy* Intracranial Arteriosclerosis / prevention & control Male Myocardial Infarction / blood, complications*, prevention & control* Prospective Studies Recurrence / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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