| Reduction of myocardial infarct size by SM-197378, a novel Na+/H+ exchange inhibitor, in rabbits. | |
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MedLine Citation:
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PMID: 16183058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of SM-197378, 2-[[[amino(imino)methyl]amino]carbonyl]-1-methyl-4-trifluoromethyl-1H-indol-7-yl=hydrogen=sulfate monohydrate, a novel potent Na+/H+exchange inhibitor, on heart injury were studied using a rabbit model involving 30 min of myocardial ischemia and 5 h of reperfusion. Intravenous administration of SM-197378 before ischemia reduced the infarct size by approximately 30-50% in a dose-dependent manner. This anti-necrotic effect was achieved without significant hemodynamic changes. Moreover, administration of SM-197378 before reperfusion also resulted in a significant, approximately 30-40%, reduction in the infarct size. The anti-necrotic effect of pre-ischemic bolus treatment with SM-197378 was compared with that of nicorandil, a K+channel opener with nitrate-like activity, and ischemic preconditioning. With 30 and 60 min of ischemia, the anti-necrotic effects of SM-197378 and ischemic preconditioning were similar and superior to that of nicorandil. With 90 min of ischemia, the anti-necrotic effect of SM-197378 was superior to that of ischemic preconditioning. |
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Authors:
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Kazuto Yamada; Kazuki Matsui; Shoji Ogawa; Setsuko Yamamoto; Masaya Mori; Masafumi Kitano; Naohito Ohashi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-09-23 |
Journal Detail:
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Title: European journal of pharmacology Volume: 521 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2006-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 115-23 Citation Subset: IM |
Affiliation:
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Sumitomo Pharmaceuticals Co., Ltd., Research Division, Japan. yamadak@sumitomopharm.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dose-Response Relationship, Drug Heart / drug effects, physiopathology Heart Rate / drug effects Indoles / pharmacology* Ischemic Preconditioning Male Myocardial Infarction / etiology, pathology, prevention & control* Myocardial Ischemia / complications Myocardial Reperfusion Injury / complications Myocardium / pathology Nicorandil / pharmacology Rabbits Sodium-Hydrogen Antiporter / antagonists & inhibitors* Time Factors Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/2-(((amino(imino)methyl)amino)carbonyl)-1-methyl-4-trifluoromethyl-1H-indol-7-yl-hydrogen-sulfate monohydrate; 0/Indoles; 0/Sodium-Hydrogen Antiporter; 0/Vasodilator Agents; 65141-46-0/Nicorandil |
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