Document Detail

Reduction of the mutagenicity of lead chromate-based pigments by encapsulation with silica.
MedLine Citation:
PMID:  2170838     Owner:  NLM     Status:  MEDLINE    
13 lead chromate-based pigments were assayed for mutagenicity and toxicity using Salmonella typhimurium TA100. The compounds were assayed with and without S9, both in the presence and absence of the chelating agent, nitrilotriacetic acid (NTA). In general, the use of NTA to solubilize the compounds resulted in mutagenicity and/or toxicity being observed where it had not in the absence of NTA, or being observed at lower concentrations than when water alone was used. Encapsulation of pigments with amorphous silica rendered these pigments non-mutagenic and non-toxic, indicating that the active moieties were biologically unavailable to the bacteria. Varying the percentage of silica encapsulation on one pigment, medium chrome yellow, indicated that 5% encapsulation did not alter the mutagenicity while 10% encapsulation inhibited the mutagenicity without or with NTA.
T H Connor; S M Pier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  245     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-16     Completed Date:  1990-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
University of Texas Health Science Center, School of Public Health, Houston 77225.
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MeSH Terms
Chromates / pharmacology*
Coloring Agents / pharmacology*
Lead / pharmacology*
Microsomes, Liver / metabolism
Mutagenicity Tests
Mutagens / pharmacology*
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Silicon Dioxide / pharmacology*
Reg. No./Substance:
0/Chromates; 0/Coloring Agents; 0/Mutagens; 11119-70-3/lead chromate; 7439-92-1/Lead; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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