Document Detail

Reduction of the monounsaturated fatty acid content of Escherichia coli K-12 results in increased resistance to oxidative damage.
MedLine Citation:
PMID:  22343353     Owner:  NLM     Status:  Publisher    
Reactive oxygen species (ROS) affect several macromolecules and cellular components in eukaryotic and prokaryotic cells. In this work, the effect of various ROS-generating compounds on the Escherichia coli membrane was studied. Membrane fatty acid profiles, oxidative damage levels and bacterial resistance to these toxicants were determined. Studies included wild type cells as well as a strain exhibiting a modified Monounsaturated Fatty Acids (MUFA) profile (accomplished by overexpressing the β-hydroxyacyl acyl carrier protein dehydratase-encoding gene, fabA). Membrane MUFA and oxidative damage markers levels decreased slightly upon toxicant exposure with a concomitant increase in cell resistance to these ROS-generating compounds. A direct relationship between MUFA and lipid peroxidation was observed. The lower the MUFA the lesser the peroxides levels, suggesting that MUFA are targets for membrane lipid oxidation.
Gonzalo A Pradenas; Braulio A Paillavil; Sebastián Reyes-Cerpa; José M Pérez; Claudio C Vásquez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Microbiology (Reading, England)     Volume:  -     ISSN:  1465-2080     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430468     Medline TA:  Microbiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Universidad de Santiago de Chile.
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