| Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. | |
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MedLine Citation:
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PMID: 20514462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extensive data indicate that miR-21 plays a critical role in gliomagenesis, however, knowledge is limited on the mechanism of action of miR-21, including cell proliferation, apoptosis, and migration. In this study, we showed that down-regulation of miR-21 expression by antisense oligonucleotides inhibited glioma cell proliferation and induced cell apoptosis. Moreover, reduction of miR-21 activated caspase 9 and 3, which may be mediated by modulating multiple potential target genes, such as TIMP3. Together, these findings indicate that miR-21 plays a key role in regulating cell apoptosis in gliomas and may serve as a target for effective therapies. |
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Authors:
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Xuan Zhou; Junxia Zhang; Qiang Jia; Yu Ren; Yingyi Wang; Lei Shi; Ning Liu; Guangxiu Wang; Peiyu Pu; Yongping You; Chunsheng Kang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 24 ISSN: 1791-2431 ISO Abbreviation: Oncol. Rep. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 195-201 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects*, genetics Brain Neoplasms / drug therapy, genetics, metabolism, pathology* Caspase 3 / metabolism* Caspase 9 / metabolism* Cell Line, Tumor Down-Regulation / drug effects, physiology Enzyme Activation / drug effects Gene Expression Regulation, Neoplastic / drug effects Glioma / drug therapy, genetics, metabolism, pathology* Humans Mice Mice, Inbred BALB C Mice, Nude MicroRNAs / antagonists & inhibitors*, genetics Oligodeoxyribonucleotides, Antisense / pharmacology*, therapeutic use Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/MIRN21 microRNA, human; 0/MicroRNAs; 0/Oligodeoxyribonucleotides, Antisense; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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