Document Detail

Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western Kenya.
MedLine Citation:
PMID:  12749486     Owner:  NLM     Status:  MEDLINE    
The impact of insecticide (permethrin)-treated bed nets (ITNs) on malaria in pregnancy was studied in a rural area in western Kenya with intense perennial malaria transmission. All households in 40 of 79 villages were randomized to receive ITNs by January 1997. The ITNs were distributed in control villages two years later. Complete data on birth outcome were available on 2,754 (89.6%) of 3,072 deliveries. Women (n = 780) were followed monthly throughout pregnancy in 19 of 79 villages. Among gravidae 1-4, ITNs were associated with reductions of 38% (95% confidence interval [CI] = 17-54%) in the incidence of malaria parasitemia and 47% (95% CI = 6-71%) in the incidence of severe malarial anemia (hemoglobin level < 8 g/dL with parasitemia) during pregnancy. At the time of delivery, mean hemoglobin levels were 0.6 g/dL (95% CI = 0.01-1.2 g/dL) higher, the prevalence of placental or maternal malaria was reduced by 35% (95% CI = 20-47%), and the prevalence of low birth weight was reduced by 28% (95% CI = 2-47%) in gravidae 1-4 from ITN villages. No beneficial impact was observed in gravidae five or higher. In areas of intense perennial malaria transmission, permethrin-treated bed nets reduce the adverse effect of malaria during the first four pregnancies.
Feiko O ter Kuile; Dianne J Terlouw; Penelope A Phillips-Howard; William A Hawley; Jennifer F Friedman; Simon K Kariuki; Ya Ping Shi; Margarette S Kolczak; Altaf A Lal; John M Vulule; Bernard L Nahlen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  68     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-16     Completed Date:  2003-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-60     Citation Subset:  AIM; IM    
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
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MeSH Terms
Antimalarials / therapeutic use
Bedding and Linens*
Cohort Studies
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
Insecticides / pharmacology*
Kenya / epidemiology
Malaria, Falciparum / epidemiology,  prevention & control*,  transmission
Multivariate Analysis
Parasitemia / drug therapy
Permethrin / pharmacology*
Pregnancy Complications, Parasitic / epidemiology,  prevention & control*
Reg. No./Substance:
0/Antimalarials; 0/Insecticides; 52645-53-1/Permethrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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