Document Detail

Reduction of lung parenchyma compliance as a factor in the genesis of pleural effusion in neoplasms.
MedLine Citation:
PMID:  11812189     Owner:  NLM     Status:  MEDLINE    
It is well known that bronchial obstruction causes an increase in negative pressure in the pleural cavity and is considered to be one of the factors giving rise to pleural fluid. We suggest that a reduction in the compliance of the lung parenchyma, whatever its cause (apart from bronchial obstruction), may also lead to an increase in negative pressure in the pleural cavity and may contribute, together with the other known factors, as an additional mechanism in the appearance of pleural fluid. We believe that this factor is valid in neoplastic pleurisy and may also apply in pleurisy, and possibly in other pathological conditions. The presence of pleural effusion may be better interpreted if we bear this factor in mind. We arrived at this view principally through the study of simple chest X-rays of normal subjects and of patients, mainly cancer patients.
V A Felekis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  58     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-28     Completed Date:  2002-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  133-5     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Harcourt Publishers Ltd.
Department of Radiology, Aghios Savvas Oncology Hospital, Athens, Greece.
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MeSH Terms
Lung Compliance / physiology*
Models, Biological
Pleural Effusion, Malignant / etiology*,  physiopathology,  radiography

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