Document Detail

Reduction of leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes by methotrexate in psoriasis.
MedLine Citation:
PMID:  3036194     Owner:  NLM     Status:  MEDLINE    
The leukotriene B4 (LTB4)-induced intraepidermal accumulation of polymorphonuclear leukocytes (PMN) was quantified, using an elastase assay, in psoriatic patients receiving methotrexate and in untreated psoriatic patients. Methotrexate in therapeutic dosages inhibited PMN infiltration in six patients who had improved considerably on treatment with the drug, a gradual increase being seen during the days on which no methotrexate was taken. Two patients were in relapse, despite methotrexate treatment, and both failed to show any change in LTB4-induced accumulation of PMN.
A M Lammers; P C van de Kerkhof; P D Mier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  116     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-07     Completed Date:  1987-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
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MeSH Terms
Leukotriene B4 / pharmacology*
Methotrexate / therapeutic use*
Middle Aged
Neutrophils / drug effects*
Psoriasis / drug therapy*,  metabolism
Skin / drug effects,  pathology
Reg. No./Substance:
59-05-2/Methotrexate; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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