| Reduction of leptin precedes fat loss from running exercise in insulin-resistant rats. | |
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MedLine Citation:
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PMID: 10595593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum concentrations of leptin, a hormone secreted into the circulation by adipocytes, correlate with body mass index. Circulating of leptin is thought to signal the brain in patients with hyperinsulinemia, a condition reported to be preventable and testable by exercise training. In the present experiments, sucrose-fed rats had reduced concentrations of leptin in portal venous blood after 4 weeks of nonforced wheel-running exercise (1.1 +/- 0.1 vs. 6.2 +/- 1.8 ng/mL, in nonexercised sucrose-fed rats, P < 0.05). Mesenteric and subcutaneous fat stores were similar between groups. After 12 weeks of exercise, portal vein levels of leptin concentrations (5.2 +/- 2.1 vs. 9.9 +/- 0.8 ng/mL, P < 0.05) and mesenteric and subcutaneous fat all were reduced in the exercise group. These results suggest that short-term running exercise reduces circulating leptin before any reduction of adipose mass, and this reduction in the concentration of leptin available to its receptors has beneficial effects on the metabolism of fat and carbohydrates. |
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Authors:
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M Nara; T Kanda; S Tsukui; T Inukai; T Umeda; S Inoue; I Kobayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 107 ISSN: 0947-7349 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-04 Completed Date: 2000-02-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: GERMANY |
Other Details:
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Languages: eng Pagination: 431-4 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Gunma University School of Medicine, Maebashi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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pathology Animals Blood Glucose / analysis Dietary Sucrose / pharmacology Insulin Resistance / physiology* Leptin / blood* Male Motor Activity / physiology* Portal Vein Rats Rats, Wistar Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Sucrose; 0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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