| Reduction of left ventricular spontaneous echo contrast in cardiomyopathy by acute inotropic intervention or aggressive therapy. | |
| | |
MedLine Citation:
|
PMID: 8821419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to determine whether improvement of left ventricular (LV) systolic function could reduce the severity or eliminate LV spontaneous echo contrast found with transthoracic echocardiography in a group of patients with advanced cardiomyopathy. A successful reduction of this by hemodynamic means might indicate an additional beneficial method of helping prevent thromboembolism in advanced cardiomyopathy. Six patients with advanced cardiomyopathy and demonstrating spontaneous echo contrast on transthoracic echocardiography were treated with acute inotropic drug infusions or aggressive medical therapy to improve LV systolic function to determine whether reduction in spontaneous contrast could be achieved by such means. A spontaneous echo contrast scoring system was devised: 0 to 4, indicating absent to severe. Six observers, unacquainted with the study plan, were blinded as to the source of the 12 pre- and post-therapy two-dimensional echocardiograms obtained and re-recorded in a random sequence, and were asked to grade the degree of spontaneous echo contrast. In all six patients, LV spontaneous echo contrast was reduced by improvement in LV systolic function (average score lowered from 2.94 to 1.25, p < 0.005). Among patients with cardiomyopathy at high risk for LV thromboembolism, as indicated by the presence of LV spontaneous echo contrast, improvement in LV systolic function may serve as an adjunct to anticoagulation or, in some cases, as a substitute when the latter is contraindicated in the prevention of thromboembolism. The results obtained suggest merit in prospective, long-term studies of a larger group of such patients. |
| | |
Authors:
|
V G Patel; A B Weisse; M Feuerman |
Related Documents
:
|
15085059 - Sustained improvement of cardiac function and prevention of cardiac remodeling after lo... 9396419 - Cardiovascular death and left ventricular remodeling two years after myocardial infarct... 11854129 - Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates le... 10073859 - Influence of left ventricular cavity size on clinical presentation in hypertrophic card... 19808359 - Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: ... 16168419 - Left ventricular shape-based contractility index. 10385759 - Cardiogenic shock complicating acute myocardial infarction: predictors of death. gusto ... 17079039 - Atypical form of left ventricular ballooning after a violent attack. 11479469 - Safety and feasibility of a novel rate-smoothed ventricular pacing algorithm for atrial... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical cardiology Volume: 19 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-11-21 Completed Date: 1996-11-21 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 105-9 Citation Subset: IM |
Affiliation:
|
Department of Medicine, UMDNJ-New Jersey Medical School and University Hospital, Newark, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cardiomyopathies / physiopathology, therapy, ultrasonography* Cardiotonic Agents / therapeutic use* Echocardiography Female Heart Ventricles / ultrasonography* Humans Male Middle Aged Myocardial Contraction / drug effects* Observer Variation Systole Thromboembolism / prevention & control Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased adhesiveness of peripheral blood leukocytes corresponds to the appearance of expansion fol...
Next Document: Importance of delaying balloon angioplasty in patients with unstable angina pectoris.