Document Detail

Reduction of left ventricular damage with intracoronary streptokinase in acute myocardial infarction.
MedLine Citation:
PMID:  6647196     Owner:  NLM     Status:  MEDLINE    
The effect of successful intracoronary thrombolysis on left ventricular function in patients with acute myocardial infarction (10 patients with anterior and 13 with inferior infarction) was compared with an untreated matched control group (14 patients with anterior and 28 with inferior infarction). Left ventricular wall motion abnormalities (LVWMA) and ejection fraction (EF) were assessed angiographically 6-8 weeks after the acute event in both groups. The severity and extent of LVWMA was less (P less than 0.01) and the EF was higher (P less than 0.01) in the treated patients with anterior infarction than in the control group. In treated patients with inferior infarction the severity of LVWMA was less (P less than 0.01) than in the control group. No significant difference was found in extent of LVWMA or in EF. These results suggest that thrombolysis reduces left ventricular damage especially in anterior myocardial infarction.
P J de Feyter; M J van Eenige; E E van der Wall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  59 Suppl 3     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
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MeSH Terms
Heart Ventricles / pathology
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*,  pathology
Streptokinase / therapeutic use*
Stroke Volume / drug effects
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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