| Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension. | |
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MedLine Citation:
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PMID: 19841522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: We assessed whether co-supplementation of vitamins C and E has additive beneficial effects on reducing the kidney damage and attenuation of the arterial pressure elevation compared to administration of either vitamin C or vitamin E alone in deoxycorticosterone acetate-salt-induced hypertension. MATERIALS AND METHODS: Forty rats were divided into 4 study groups and 1 sham-operated group. Unilateral nephrectomy was carried out in the study groups and hypertension was induced by deoxycorticosterone injection and 1% sodium chloride and 0.2% potassium chloride added to the drinking water. Vitamins C and E (200 mg/kg/day) or combination of them were administered with DOCA-salt for 4 weeks in 3 study groups. The effects of DOCA and salt and treatment with vitamins were compared in terms of blood pressure, urinary protein excretion, antioxidant activity of the kidneys, and renal histological changes. RESULTS: Four weeks of supplementations of vitamins C, vitamin E, and both in the DOCA-salt-treated rats had comparable significant effects in decreasing systolic blood pressure. Urinary protein excretion and histological damage did not significantly change with the combination therapy of vitamins C and E compared to the vitamin C or E alone. The renal levels of glutathione and ferric reducing/antioxidant power in combination therapy group were similar to the two other treatment groups and were significantly higher than non-treated group. CONCLUSIONS: Co-administration of vitamin C and E does not have an additive beneficial effect on reducing the kidney damage and hypertension compared to either vitamin C or E alone in DOCA-salt-induced hypertension. |
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Authors:
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Behjat Seifi; Mehri Kadkhodaee; Seyed Morteza Karimian; Maryam Zahmatkesh; Sedighe Shams; Enayatolla Bakhshi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Iranian journal of kidney diseases Volume: 3 ISSN: 1735-8582 ISO Abbreviation: Iran J Kidney Dis Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-20 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316967 Medline TA: Iran J Kidney Dis Country: Iran |
Other Details:
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Languages: eng Pagination: 197-202 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / therapeutic use* Ascorbic Acid / therapeutic use* Calcium Chloride Desoxycorticosterone Dietary Supplements Disease Models, Animal Drug Therapy, Combination Hypertension / drug therapy*, etiology, pathology Kidney Diseases / drug therapy*, etiology, pathology Male Potassium Chloride Rats Rats, Sprague-Dawley Vitamin E / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 10043-52-4/Calcium Chloride; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 64-85-7/Desoxycorticosterone; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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