Document Detail

Reduction of ischemic, pharmacological and remote preconditioning effects by an antioxidant N-acetyl cysteine pretreatment in isolated rat heart.
MedLine Citation:
PMID:  18311068     Owner:  NLM     Status:  MEDLINE    
The present study was designed to investigate the possible role of free radicals in cardioprotective effects of ischemic, pharmacological and remote preconditioning. Isolated rat heart was perfused on Langendorff apparatus with Kreb's Henseleit solution and subjected to 30 min global ischemia followed by 120 min reperfusion. To assess myocardial injury, coronary effluent was analyzed for lactate dehydrogenase and creatine kinase activity. Myocardial infarct size was estimated using triphenyl tetrazolium chloride staining. Ischemic preconditioning, pharmacological preconditioning (angiotensin II; H2O2), remote aortic preconditioning markedly attenuated I/R induced increase in lactate dehydrogenase and creatine kinase release and myocardial infarct size. Administration of N-Acetyl Cysteine (NAC), in vitro, during ischemic and pharmacological, and in vivo during remote preconditioning attenuated the cardioprotective effects of preconditioning. On the basis of these results, it may be concluded that sub threshold generation of Reactive Oxygen Species (ROS) may activate redox signaling which may be responsible for preconditioning induced cardioprotection.
Gitika Khanna; Vishal Diwan; Manjeet Singh; Nirmal Singh; Amteshwar S Jaggi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  128     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  469-77     Citation Subset:  IM    
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Punjab, India.
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MeSH Terms
Acetylcysteine / pharmacology*
Angiotensin II
Cardiotonic Agents / antagonists & inhibitors,  pharmacology*
Free Radical Scavengers / pharmacology*
Hydrogen Peroxide
Ischemic Preconditioning*
Myocardial Infarction / prevention & control
Oxidation-Reduction / drug effects
Rats, Wistar
Reactive Oxygen Species / antagonists & inhibitors,  pharmacology*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 11128-99-7/Angiotensin II; 616-91-1/Acetylcysteine; 7722-84-1/Hydrogen Peroxide

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