| Reduction of ischemic, pharmacological and remote preconditioning effects by an antioxidant N-acetyl cysteine pretreatment in isolated rat heart. | |
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MedLine Citation:
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PMID: 18311068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to investigate the possible role of free radicals in cardioprotective effects of ischemic, pharmacological and remote preconditioning. Isolated rat heart was perfused on Langendorff apparatus with Kreb's Henseleit solution and subjected to 30 min global ischemia followed by 120 min reperfusion. To assess myocardial injury, coronary effluent was analyzed for lactate dehydrogenase and creatine kinase activity. Myocardial infarct size was estimated using triphenyl tetrazolium chloride staining. Ischemic preconditioning, pharmacological preconditioning (angiotensin II; H2O2), remote aortic preconditioning markedly attenuated I/R induced increase in lactate dehydrogenase and creatine kinase release and myocardial infarct size. Administration of N-Acetyl Cysteine (NAC), in vitro, during ischemic and pharmacological, and in vivo during remote preconditioning attenuated the cardioprotective effects of preconditioning. On the basis of these results, it may be concluded that sub threshold generation of Reactive Oxygen Species (ROS) may activate redox signaling which may be responsible for preconditioning induced cardioprotection. |
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Authors:
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Gitika Khanna; Vishal Diwan; Manjeet Singh; Nirmal Singh; Amteshwar S Jaggi |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 128 ISSN: 0031-6903 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 469-77 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Punjab, India. gitikagitika@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology* Angiotensin II Animals Cardiotonic Agents / antagonists & inhibitors, pharmacology* Female Free Radical Scavengers / pharmacology* Hydrogen Peroxide Ischemic Preconditioning* Male Myocardial Infarction / prevention & control Oxidation-Reduction / drug effects Rats Rats, Wistar Reactive Oxygen Species / antagonists & inhibitors, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 11128-99-7/Angiotensin II; 616-91-1/Acetylcysteine; 7722-84-1/Hydrogen Peroxide |
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