Document Detail

Reduction of influenza virus titer and protection against influenza virus infection in infant mice fed Lactobacillus casei Shirota.
MedLine Citation:
PMID:  15242940     Owner:  NLM     Status:  MEDLINE    
We investigated whether oral administration of Lactobacillus casei strain Shirota to neonatal and infant mice ameliorates influenza virus (IFV) infection in the upper respiratory tract and protects against influenza infection. In a model of upper respiratory IFV infection, the titer of virus in the nasal washings of infant mice administered L. casei Shirota (L. casei Shirota group) was significantly (P < 0.05) lower than that in infant mice administered saline (control group) (10(2.48) +/- 10(0.31) and 10(2.78) +/- 10(0.4), respectively). Further, the survival rate of the L. casei Shirota group was significantly (P < 0.05) higher than that of the control group (14.3 versus 40.0%). One day after infection, pulmonary NK cell activity and interleukin-12 production by mediastinal lymph node cells of mice in the L. casei Shirota group were significantly greater than those of mice in the control group. These findings suggest that oral administration of L. casei Shirota activates the immature immune system of neonatal and infant mice and protects against IFV infection. Therefore, oral administration of L. casei Shirota may accelerate the innate immune response of the respiratory tract and protect against various respiratory infections in neonates, infants, and children, a high risk group for viral and bacterial infections.
Hisako Yasui; Junko Kiyoshima; Tetsuji Hori
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and diagnostic laboratory immunology     Volume:  11     ISSN:  1071-412X     ISO Abbreviation:  Clin. Diagn. Lab. Immunol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-09     Completed Date:  2005-01-13     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9421292     Medline TA:  Clin Diagn Lab Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-9     Citation Subset:  IM    
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
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MeSH Terms
Administration, Oral
Age Factors
Animals, Newborn
Disease Models, Animal
Interleukin-12 / immunology
Killer Cells, Natural / immunology
Lactobacillus casei / immunology*
Nasal Lavage Fluid / virology
Orthomyxoviridae / immunology
Orthomyxoviridae Infections / prevention & control*
Respiratory Tract Infections / immunology,  prevention & control*,  virology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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