Document Detail


Reduction of infarct size in patients with inferior infarction with intravenous glyceryl trinitrate. A randomised study.
MedLine Citation:
PMID:  6404289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glyceryl trinitrate was previously said to be contraindicated in patients with acute myocardial infarction. Its intravenous administration during acute infarction, however, was associated with a beneficial effect as determined by ST segment mapping. Most recently in a selected group of patients with acute infarction and abnormal haemodynamics, intravenous glyceryl trinitrate was shown to reduce infarct size estimated by enzymes. The present study was performed to verify the safety of intravenous glyceryl trinitrate in patients with infarction under conventional clinical conditions without invasive monitoring and to determine its effect on infarct size in a prospective randomised trial involving 85 patients with infarction (43 treated and 42 control). Treated patients received glyceryl trinitrate within 10 hours of the onset of symptoms (mean 6.0 hours), and the dose was titrated to preset limits for changes in heart rate and blood pressure. In patients with inferior infarction, infarct size estimated by enzymes in the treated was only 12.2 +/- 1.8 versus 19.1 +/- 3.6 CK gram equivalents per metre squared in the placebo group. A similar but statistically insignificant trend was observed for subendocardial infarction but no difference was observed for anterior infarction. Ventricular arrhythmias determined from 24 hour tapes were more frequent in treated patients though this was not statistically significant. Lignocaine requirements in treated and control (1692 +/- 250 vs 1512 +/- 232 mg/24 h) were similar, as were the requirements for morphine (11.4 +/- 1.8 vs 12.2 +/- 2.2 mg/24 h). Results indicate that intravenous glyceryl trinitrate can be administered safely during evolving infarction without invasive monitoring and reduces infarct size in patients with inferior infarction.
Authors:
A S Jaffe; E M Geltman; A J Tiefenbrunn; H D Ambos; H D Strauss; B E Sobel; R Roberts
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British heart journal     Volume:  49     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  452-60     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arrhythmias, Cardiac / etiology
Blood Pressure / drug effects
Clinical Trials as Topic
Female
Heart Rate / drug effects
Humans
Infusions, Parenteral
Male
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Nitroglycerin / administration & dosage,  therapeutic use*
Random Allocation
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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