| Reduction in trunk fat predicts cardiovascular exercise training-related reductions in C-reactive protein. | |
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MedLine Citation:
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PMID: 19486651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. We sought to determine (1) if 10 months of cardiovascular exercise training (Cardio) reduces CRP in a group of older adults, (2) if such a reduction is related to improvements in trunk fat, fitness, and/or psychosocial variables, and (3) if the effect of Cardio on CRP differs between men and women. Community-dwelling residents (n=127; 60-83 yrs) were randomized to a Flex group (n=61) where they participated in 2-75 min supervised sessions per wk during which they performed non-cardiovascular flexibility and balance exercises or a Cardio group (n=66) where they participated in three supervised sessions per wk during which they performed cardiovascular exercises for approximately 45-60 min at 60-70% maximal oxygen uptake. The main outcome measures were serum CRP, cardiovascular fitness, total and central adiposity, and self-reported psychosocial function. Cardio experienced a reduction in CRP (-0.5mg/L), as well as improvements in fitness (+7%) and total (-1.5%) and central (i.e., trunk) (-2.5%) adiposity. These relationships were not modified by sex. Regression analyses indicated that only the reduction in trunk fat was significantly related to the reduction in CRP. Ten months of cardiovascular exercise training reduced CRP in previously sedentary older adults and this effect was partially mediated by a reduction in trunk fat. |
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Authors:
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V J Vieira; L Hu; R J Valentine; E McAuley; E M Evans; T Baynard; J A Woods |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-01-29 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 23 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2009-12-09 Revised Date: 2010-02-22 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 485-91 Citation Subset: IM |
Affiliation:
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Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers Body Composition Body Fat Distribution* C-Reactive Protein / metabolism* Cardiovascular Diseases / etiology Cardiovascular System / metabolism* Enzyme-Linked Immunosorbent Assay Exercise Therapy* Female Humans Male Middle Aged Neuropsychological Tests Patient Selection Physical Fitness Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG-18861/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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