| Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: A double-blind randomised, placebo-controlled study. | |
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MedLine Citation:
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PMID: 22100822 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, we evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section. METHODS: Fifty-two parturients scheduled for elective caesarean section were randomly allocated into two groups. Before induction of spinal anaesthesia Group O (n=26) received intravenous ondansetron 4mg; Group S (n=26) received normal saline. Blood pressure, heart rate and vasopressor requirements were assessed. RESULTS: Decreases in mean arterial pressure were significantly lower in Group O than Group S from 14min until 35min. Patients in Group O required significantly less vasopressor (P=0.009) and had significantly lower incidences of nausea and vomiting (P=0.049). CONCLUSION: Ondansetron 4mg, given intravenously 5min before subarachnoid block reduced hypotension and vasopressor use in parturients undergoing elective caesarean section. |
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Authors:
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T Sahoo; C Sendasgupta; A Goswami; A Hazra |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: International journal of obstetric anesthesia Volume: - ISSN: 1532-3374 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200430 Medline TA: Int J Obstet Anesth Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anaesthesiology, Institute of Post Graduate Medical Education & Research, Kolkata, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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