Document Detail

Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study.
MedLine Citation:
PMID:  22100822     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, we evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section.
METHODS: Fifty-two parturients scheduled for elective caesarean section were randomly allocated into two groups. Before induction of spinal anaesthesia Group O (n=26) received intravenous ondansetron 4 mg; Group S (n=26) received normal saline. Blood pressure, heart rate and vasopressor requirements were assessed.
RESULTS: Decreases in mean arterial pressure were significantly lower in Group O than Group S from 14 min until 35 min. Patients in Group O required significantly less vasopressor (P=0.009) and had significantly lower incidences of nausea and vomiting (P=0.049).
CONCLUSION: Ondansetron 4 mg, given intravenously 5 min before subarachnoid block reduced hypotension and vasopressor use in parturients undergoing elective caesarean section.
T Sahoo; C SenDasgupta; A Goswami; A Hazra
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-11-18
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  21     ISSN:  1532-3374     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-05-11     Revised Date:  2012-11-27    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Anaesthesiology, Institute of Post Graduate Medical Education & Research, Kolkata, India.
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MeSH Terms
Anesthesia, Obstetrical / adverse effects*
Anesthesia, Spinal / adverse effects*
Blood Pressure / drug effects
Cesarean Section
Double-Blind Method
Heart Rate / drug effects
Hypotension / prevention & control*
Ondansetron / therapeutic use*
Receptors, Serotonin, 5-HT3 / physiology
Serotonin Antagonists / therapeutic use*
Reg. No./Substance:
0/Receptors, Serotonin, 5-HT3; 0/Serotonin Antagonists; 99614-02-5/Ondansetron
Comment In:
Int J Obstet Anesth. 2012 Oct;21(4):380; author reply 380   [PMID:  22858045 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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